Genome Health Clinics Not Far Away

Nutrition

Clinics that can test for consumers' genotypes and give out dietary advice based on findings could be set up in the near future, according to an Australian scientist speaking at Asia's first major nutrigenomics conference last week.

Dr Michael Fenech, head of the Nutrigenomics and Genome Health project funded by Australia's research body CSIRO, told those attending the meeting in Singapore that 'genome health clinics' will soon be possible as knowledge on gene-diet interactions grows.

"There is good evidence that genome and epigenome damage 'markers' are sensitive indicators of deficiency or excess in micronutrients (vitamins and minerals) which are needed as components of DNA repair enzymes and/or to make new copies of DNA," he said.

"We now know that moderate micronutrient deficiency can cause as much genome damage as significant doses of radiation and increases the risk of developmental and degenerative disease."

A deficiency of micronutrients can limit the DNA's ability to replicate itself properly and thus reduce the body’s ability to fight diseases. Growing work in this area is creating a new opportunity in disease prevention based on the fact that genome damage caused by micronutrient deficiency is preventable.

"Specific micronutrient deficiencies that cause genome damage may themselves cause developmental defects in the foetus or increased risk of cancer later in life. Supplementation of diet with appropriate vitamins, such as folate and B12, at the correct dose for each individual could help our DNA to remain healthy, and in some cases, actually help to repair damaged DNA," said Fenech.

According to Dr Fenech, in the future consumers could take a simple blood test at a special clinic and have the damage to their DNA assessed as well as their genotype determined. From there, they would be offered a micronutrient supplement and diet plan tailored to optimise their health.

I find these developments and the research and funding attention being invested to be very refreshing, even exciting. It demonstrates clear recognition of the importance of micronutrition with vitamins and minerals, including the absolutely foundational role this area plays in health. It also strongly supports the notion that I and many others have been saying for many years; beyond certain basics everyone's individual nutritional needs can vary markedly from person to person.

It is good to see high quality, government funded research attention being focussed on the importance of individual nutrition. Sure beats all that medical toxicity!

More details on Dr Michael Fenech's Nutrigenomics

For those who would like to follow up this post by reading Dr Fenech's recent paper on the topic the following should prove helpful.

The citation:

Fenech M. The Genome Health Clinic and Genome Health Nutrigenomics concepts: diagnosis and nutritional treatment of genome and epigenome damage on an individual basis. Mutagenesis. 2005 Jul;20(4):255-69. Epub 2005 Jun 14.

The abstract:

The evidence of a direct link between increased genome/epigenome damage and elevated risk for adverse health outcomes during the various stages of life, such as infertility, foetal development and cancer is becoming increasingly stronger. The latter is briefly reviewed against a background of evidence indicating that genome and epigenome damage biomarkers, in the absence of overt exposure of genotoxins, are themselves sensitive indicators of deficiency in micronutrients required as cofactors or as components of DNA repair enzymes, for maintenance methylation of CpG sequences and prevention of DNA oxidation and/or uracil incorporation into DNA. The latter is illustrated with cross-sectional and dietary intervention data obtained using the micronucleus assay and other efficient biomarkers for diagnosing genome and/or epigenome instability. The concept of recommended dietary allowances for genome stability and how this could be achieved is discussed. The 'Genome Health Nutrigenomics' concept is also introduced to define and focus attention on the specialized research area of how diet impacts on genome stability and how genotype determines nutritional requirements for genome health maintenance. The review concludes with a vision for a paradigm shift in disease prevention strategy based on the diagnosis and nutritional treatment of genome/epigenome damage on an individual basis, i.e. The Genome Health Clinic.

Nutrigenomics seems to be on the right track

The work Dr Fenech is doing is the most interesting and seemingly 'right-footed' I have encountered in a very long time. There is far too much 'junk science' these days and much work is wasted, not so much due to lack of skills, but because distorted values mean that the wrong questions are being asked, usually over and over again. It doesn't matter how many times you ask the wrong question, it never leads to the right answer.

I encourage everyone with an interest to explore this further.

Peter
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Dr Peter Tylee
Editor